Job Family:

Travel Required:

Clearance Required:

What You Will Do:

We are currently searching for Scientist to independently provide support services to satisfy the overall operational objectives of the National Institute of Allergy and Infectious Diseases (NIAID). This is a full-time, on-site opportunity in Gaithersburg, MD.

• Plan and execute the generation of stable cell lines for preclinical and clinical material production to advance candidates including monoclonal antibodies, recombinant proteins, and virus like particles.
• Use molecular biology techniques, including RT-PCR and NGS (Next-generation sequencing), for genetic characterization of cell lines.
• Perform gene synthesis including oligo synthesis, plasmid design, and construction.
• Independently execute all steps of the process including plasmid construction, stable pool generation, single cell cloning, and top clone selection.
• Draft and verify data for CMC (Chemistry, Manufacturing, and Controls) sections of pre-IND (Investiational New Drug) and IND documents to ensure successful registration of candidates.
• Design, perform, and troubleshoot experiments and analyze data for both development and deliverable projects.
• Maintain and support one or more pieces of laboratory instrumentation.
• Identify, propose, and execute process and procedural changes to improve performance, robustness, productivity, and efficiency by reviewing recent literature and new technologies.
• Develop and track timelines and experimental plans for multiple projects simultaneously and regularly review records of tasks performed by other team members.
• Prepare oral presentations and posters for internal and external groups/conferences.
• Present results of clinical and experimental research at recognized scientific meetings by lectures and exhibits (poster sessions).
• Generate, maintain, and review accurate daily records of experiments and results in a laboratory notebook.
• Prepare and review experimental plans, proposals, reports, SOPs, and production records.
• Train staff on the proper usage of equipment.

What You Will Need:

• PhD in biological science or related field with at least two (2) years of experience or master’s degree with at least four (4) years of experience with the development of stable cell lines for vaccine and biotherapeutic candidates within an industrial setting.
• Expertise in molecular biology techniques for genetic characterization of cell lines, including, but not limited to, RT-PCR and NGS
• Hands-on experience with multiple supporting technologies for cell line engineering such as cell counting, high-throughput transfection, single-cell cloning/ deposition, flow cytometry, automated liquid handling systems, and/ or automated small-scale bioreactor systems.
• Extensive hands-on experience with aseptic technique and mammalian cell culture to generate clonally derived cell lines used to produce monoclonal antibodies or vaccine candidates
• Demonstrated ability to produce and screen hundreds of clonally derived CHO or 293 cell lines for top performers.

• Must be able to obtain and maintain a Federal or DoD “public trust”; candidates must receive approved adjudication prior to onboarding with Guidehouse. Candidates with an active public trust or suitability are preferred.

What Would Be Nice To Have:

• Be able to independently design experiments and work plans and manage project timelines for multiple complex projects simultaneously.
• Expertise in designing and constructing plasmids for gene expression using molecular cloning methods.
• Experience in preparing technical reports, SOPs, data presentations, and documents needed for technology transfer and regulatory filing is desired.
• Strong verbal and written communication skills.
• Proficient in MS Office Suite.

What We Offer:

Guidehouse offers a comprehensive, total rewards package that includes competitive compensation and a flexible benefits package that reflects our commitment to creating a diverse and supportive workplace.

Benefits include:

• Medical, Rx, Dental & Vision Insurance

• Personal and Family Sick Time & Company Paid Holidays

• Parental Leave

• 401(k) Retirement Plan

• Group Term Life and Travel Assistance

• Voluntary Life and AD&D Insurance

• Health Savings Account, Health Care & Dependent Care Flexible Spending Accounts

• Transit and Parking Commuter Benefits

• Short-Term & Long-Term Disability

• Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities

• Employee Referral Program

• Corporate Sponsored Events & Community Outreach

• Care.com annual membership

• Employee Assistance Program

• Supplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and ID theft protection, etc.)

• Position may be eligible for a discretionary variable incentive bonus

About Guidehouse

Guidehouse is an Equal Opportunity Employer-Protected Veterans, Individuals with Disabilities or any other basis protected by law, ordinance, or regulation.

Guidehouse will consider for employment qualified applicants with criminal histories in a manner consistent with the requirements of applicable law or ordinance including the Fair Chance Ordinance of Los Angeles and San Francisco.

If you have visited our website for information about employment opportunities, or to apply for a position, and you require an accommodation, please contact Guidehouse Recruiting at 1-571-633-1711 or via email at RecruitingAccommodation@guidehouse.com" target="_blank">RecruitingAccommodation@guidehouse.com. All information you provide will be kept confidential and will be used only to the extent required to provide needed reasonable accommodation.

All communication regarding recruitment for a Guidehouse position will be sent from Guidehouse email domains including @guidehouse.com or guidehouse@myworkday.com" target="_blank">guidehouse@myworkday.com.  Correspondence received by an applicant from any other domain should be considered unauthorized and will not be honored by Guidehouse.  Note that Guidehouse will never charge a fee or require a money transfer at any stage of the recruitment process and does not collect fees from educational institutions for participation in a recruitment event. Never provide your banking information to a third party purporting to need that information to proceed in the hiring process.

If any person or organization demands money related to a job opportunity with Guidehouse, please report the matter to Guidehouse’s Ethics Hotline. If you want to check the validity of correspondence you have received, please contact recruiting@guidehouse.com" target="_blank">recruiting@guidehouse.com. Guidehouse is not responsible for losses incurred (monetary or otherwise) from an applicant’s dealings with unauthorized third parties.

Guidehouse does not accept unsolicited resumes through or from search firms or staffing agencies. All unsolicited resumes will be considered the property of Guidehouse and Guidehouse will not be obligated to pay a placement fee.